Article

Strong epistasis constrains the evolution of strict substrate specificity in apicomplexan lactate dehydrogenases

2023-06-24

Abstract excerpt

The homologous enzymes lactate and malate dehydrogenase (L/MDH) are structurally similar but are specific for different substrates. LDH vs MDH specificity is canonically governed by the identity of a single “specificity residue” at position 102. However, LDH function has convergently evolved from a specific MDH at least four times, and the catalytic role of residue 102 is not conserved between different phyla. The...

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Literature Corpus work: bc2e94b6-a6db-5e59-856e-33a4bcdc280a
DOI: 10.1101/2023.06.21.545977

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