Article
Allostery and Evolution: A Molecular Journey Through the Structural and Dynamical Landscape of an Enzyme Super Family.
Molecular biology and evolution - 6 Jan 2025
Coquille Sandrine, Pereira Caroline Simões, Roche Jennifer, Santoni Gianluca, Engilberge Sylvain, Brochier-Armanet Céline, Girard Eric, Sterpone Fabio, Madern Dominique
Abstract excerpt
Allosteric regulation is a powerful mechanism for controlling the efficiency of enzymes. Deciphering the evolutionary mechanisms by which allosteric properties have been acquired in enzymes is of fundamental importance. We used the malate (MalDH) and lactate deydrogenases (LDHs) superfamily as model to elucidate this phenomenon. By introducing a few of mutations associated to the emergence of allosteric LDHs into...
Read the complete abstract on PubMedTopics
- Allosteric Regulation
- Molecular Dynamics Simulation
- Evolution, Molecular
- Malate Dehydrogenase
- Catalytic Domain