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Article

An atomic-resolution view of neofunctionalization in the evolution of apicomplexan lactate dehydrogenases.

eLife - 25 Jun 2014

Boucher Jeffrey I, Jacobowitz Joseph R, Beckett Brian C, Classen Scott, Theobald Douglas L

Abstract excerpt

Malate and lactate dehydrogenases (MDH and LDH) are homologous, core metabolic enzymes that share a fold and catalytic mechanism yet possess strict specificity for their substrates. In the Apicomplexa, convergent evolution of an unusual LDH from MDH produced a difference in specificity exceeding 12 orders of magnitude. The mechanisms responsible for this extraordinary functional shift are currently unknown. Using...

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Identifiers

PMID: 24966208
DOI: 10.7554/eLife.02304
PMCID: PMC4109310

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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