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Article

A widened substrate selectivity filter of eukaryotic formate-nitrite transporters enables high-level lactate conductance.

The FEBS journal - 1 Aug 2017

Wiechert Marie, Erler Holger, Golldack André, Beitz Eric

Abstract excerpt

Bacterial formate-nitrite transporters (FNT) regulate the metabolic flow of small weak mono-acids derived from anaerobic mixed-acid fermentation, such as formate, and further transport nitrite and hydrosulfide. The eukaryotic Plasmodium falciparumFNT is vital for the malaria parasite by its ability to release the larger l-lactate substrate as the metabolic end product of anaerobic glycolysis in symport with...

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PMID: 28544379
DOI: 10.1111/febs.14117

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