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Article

Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation.

Analytical and bioanalytical chemistry - 1 Nov 2008

Zanger Ulrich M, Turpeinen Miia, Klein Kathrin, Schwab Matthias

Abstract excerpt

We investigated the elimination routes for the 200 drugs that are sold most often by prescription count in the United States. The majority (78%) of the hepatically cleared drugs were found to be subject to oxidative metabolism via cytochromes P450 of the families 1, 2 and 3, with major contributions from CYP3A4/5 (37% of drugs) followed by CYP2C9 (17%), CYP2D6 (15%), CYP2C19 (10%), CYP1A2 (9%), CYP2C8 (6%), and...

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PMID: 18695978
DOI: 10.1007/s00216-008-2291-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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