Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Parallel High-Throughput RNA Interference Screens Identify PINK1 as a Potential Therapeutic Target for the Treatment of DNA Mismatch Repair–Deficient Cancers

17 Jan 2011

Abstract excerpt

Synthetic lethal approaches to cancer treatment have the potential to deliver relatively large therapeutic windows and therefore significant patient benefit. To identify potential therapeutic approaches for cancers deficient in DNA mismatch repair (MMR), we have carried out parallel high-throughput RNA interference screens using tumor cell models of MSH2- and MLH1-related MMR deficiency. We show that silencing of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Repair Mechanisms
Share to Genetic factors in colorectal cancer
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21242281
DOI: 10.1158/0008-5472.can-10-2836

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Parallel High-Throughput RNA Interference Screens Identify PINK1 as a Potential Therapeutic Target for the Treatment of DNA Mismatch Repair–Deficient CancersPMID 21242281Read ↗

MLH1 deficiency leads to deregulated mitochondrial metabolism.Semantic proximity Read ↗

SOD1 is a synthetic-lethal target in PPM1D-mutant leukemia cells.Semantic proximity Read ↗

<i>SOD1</i> is a synthetic lethal target in <i>PPM1D</i> -mutant leukemia cellsSemantic proximity Read ↗

Mutations in DNA mismatch repair genes: implications for DNA damage signaling and drug sensitivity (review).Semantic proximity Read ↗

Mismatch Repair-Deficient Cancers Are Targets for Anti-PD-1 TherapySemantic proximity Read ↗

A functional cancer genomics screen identifies a druggable synthetic lethal interaction between MSH3 and PRKDC.Semantic proximity Read ↗

Human MLH1 protein participates in genomic damage checkpoint signaling in response to DNA interstrand crosslinks, while MSH2 functions in DNA repair.Semantic proximity Read ↗

A synthetic lethal screen reveals enhanced sensitivity to ATR inhibitor treatment in mantle cell lymphoma with ATM loss-of-function.Semantic proximity Read ↗

Mismatch repair dissection by in vivo RNAi reveals dose-dependent modulators of somatic instability and proteome remodeling in Huntington’s diseaseSemantic proximity Read ↗

Clinical prospects of WRN inhibition as a treatment for MSI tumoursSemantic proximity Read ↗

Functional Genomic Screen in Mesothelioma Reveals that Loss of Function of BRCA1-Associated Protein 1 Induces Chemoresistance to Ribonucleotide Reductase InhibitionSemantic proximity Read ↗

Genomic Instability Promoted by Overexpression of Mismatch Repair Factors in Yeast: A Model for Understanding Cancer ProgressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.