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TRIM21-Mediated Ubiquitination of FBL Suppresses PI3K/AKT Signaling and Tumor Progression in Clear Cell Renal Cell Carcinoma

2025-10-20

Abstract excerpt

<title>Abstract</title> <p>Transcriptional reprogramming mediated by oncogenic C-Myc is a hallmark of clear cell renal cell carcinoma (ccRCC). By integrating single-cell RNA-seq, bulk transcriptomic, and proteomic datasets, we identified the nucleolar protein fibrillarin (FBL)—a known C-Myc target—as significantly overexpressed in ccRCC. This upregulation was associated with adverse clinical outcomes and critical...

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Literature Corpus work: bbc126d6-18ab-55a8-acf1-47052a4dc0fc
DOI: 10.21203/rs.3.rs-7792839/v1

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