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The Deubiquitinase USP2 Inhibits Clear Cell Renal Cell Carcinoma by Activating the p53 Signaling Pathway and Inducing Ferroptosis

2026-01-22

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<title>Abstract</title> <p>Background Clear cell renal cell carcinoma (ccRCC) remains lethal in 40% of patients because of intrinsic resistance to VEGF- and immune-targeted therapies. The deubiquitinase (DUB) family has been implicated in tumour–immune crosstalk, but a systems-level portrait and functional driver gene are still lacking. Methods Multi-cohort transcriptomic profiles (TCA-KIRC, n = 528; E-MTAB-198...

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Literature Corpus work
db1aeb8c-16c0-5184-b694-8625c798ade0
DOI
10.21203/rs.3.rs-8166530/v1
Open publication

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