Article

ACE1 knockout in neurons selectively dysregulates the hippocampal renin angiotensin system and causes vascular loss

2024-02-23

Abstract excerpt

Angiotensin I converting enzyme (ACE1) maintains blood pressure homeostasis by converting angiotensin I (angI) into angiotensin II (angII) in the renin-angiotensin system (RAS). ACE1 is expressed in the brain, where an intrinsic RAS regulates complex cognitive functions including learning and memory. ACE1 has been implicated in neurodegenerative disorders including Alzheimer’s disease (AD) and Parkinson’s disease...

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Literature Corpus work: bb963400-96b9-5697-9a0d-c19b17e16c99
DOI: 10.1101/2024.02.21.581402

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