Article

Colonoid-Based Transcriptomics Reveals Conserved and Model-Specific Mechanisms of Doxorubicin-Induced Intestinal Toxicity

2026-06-26

Abstract excerpt

Animal models are standard for safety evaluation, yet physiological differences limit human translation. Doxorubicin (DOX), a chemotherapeutic, can cause off-target gastrointestinal (GI) toxicity and treatment discontinuation. This study evaluated human colonoids as a potential human-relevant epithelial model for DOX-induced GI toxicity by comparing transcriptomic responses across human colonoids, mouse colonoids,...

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Literature Corpus work: bb5d4558-5e6b-5fe1-a5ec-504602d5f1d1
DOI: 10.20944/preprints202606.1996.v1

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