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Article

Survey of Human Chromosome 21 Gene Expression Effects on Early Development in Danio rerio.

G3 (Bethesda, Md.) - 2 Jul 2018

Edie Sarah, Zaghloul Norann A, Leitch Carmen C, Klinedinst Donna K, Lebron Janette, Thole Joey F, McCallion Andrew S, Katsanis Nicholas, Reeves Roger H

Abstract excerpt

Trisomy for human chromosome 21 (Hsa21) results in Down syndrome (DS), one of the most genetically complex conditions compatible with human survival. Assessment of the physiological consequences of dosage-driven overexpression of individual Hsa21 genes during early embryogenesis and the resulting contributions to DS pathology in mammals are not tractable in a systematic way. A recent study looked at...

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Share to Chromosomes, Human, Pair 21
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29760202
DOI: 10.1534/g3.118.200144
PMCID: PMC6027891

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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