Article

Survey of human chromosome 21 gene expression effects on early development in <i>Danio rerio</i>

2018-02-22

Abstract excerpt

<h4>ABSTRACT:</h4> Trisomy for human chromosome 21 (Hsa21) results in Down syndrome (DS), one of the most genetically complex conditions compatible with human survival. Assessment of the physiological consequences of dosage-driven overexpression of individual Hsa21 genes during early embryogenesis and the resulting contributions to DS pathology in mammals are not tractable in a systematic way. A recent study look...

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Literature Corpus work: a7941988-b579-5bc1-9a6b-978094e618bb
DOI: 10.1101/269944

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