Article

Chr21 protein-protein interactions: enrichment in products involved in intellectual disabilities, autism and Late Onset Alzheimer Disease

2019-12-12

Abstract excerpt

<h4>ABSTRACT</h4> Intellectual disability (ID) found in Down syndrome (DS), which is characterized by an extra copy of 234 genes on Chr21 is poorly understood. We first used two DS mouse models that either display an extra copy of the Dyrk1A gene or of the mouse Chr16 syntenic region. Exome sequencing of transcripts deregulated in embryonic hippocampus uncovers enrichment in genes involved in chromatin and synap...

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Literature Corpus work: cff360e1-35d1-57df-bddd-6486555fe81e
DOI: 10.1101/2019.12.11.872606

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