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All Creatures Great and Small: New Approaches for Understanding Down Syndrome Genetics

20 Oct 2020

Abstract excerpt

Human chromosome 21 (Hsa21) contains more than 500 genes, making trisomy 21 one of the most complex genetic perturbations compatible with life. The ultimate goal of Down syndrome (DS) research is to design therapies that improve quality of life for individuals with DS by understanding which subsets of Hsa21 genes contribute to DS-associated phenotypes throughout the lifetime. However, the complexity of DS...

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PMID: 33097276
DOI: 10.1016/j.tig.2020.09.017

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