Article

Germ cell connectivity enhances cell death in response to DNA damage in <i>Drosophila</i> testis

2017-04-27

Abstract excerpt

Two broadly known characteristics of germ cells in many organisms are their development as a ‘cyst’ of interconnected cells and their high sensitivity to DNA damage. Here we provide evidence that these characteristics are linked, and that interconnectivity is a mechanism that confers to the Drosophila testis a high sensitivity to DNA damage. We show that all germ cells within a cyst die simultaneously even when o...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0082ceba-9a7b-51b2-bcd2-6771d6729cda
DOI: 10.1101/131425

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Germ cell connectivity enhances cell death in response to DNA damage in <i>Drosophila</i> testisDOI 10.1101/131425Read

Germ cell connectivity enhances cell death in response to DNA damage in the Drosophila testisSemantic proximity Read

Tolerance thresholds underlie responses to DNA damage during germline developmentSemantic proximity Read

A somatic permeability barrier around the germline is essential for<i>Drosophila</i>spermatogenesisSemantic proximity Read

Daughterless coordinates somatic cell proliferation, differentiation and germline cyst survival during follicle formation in Drosophila.Semantic proximity Read

Trajectory Mapping of the Early <i>Drosophila</i> Germline Reveals Controls of Zygotic Activation and Sex DifferentiationSemantic proximity Read

Zebrafish <i>dazl</i> regulates cystogenesis upstream of the meiotic transition and germline stem cell specification and independent of meiotic checkpointsSemantic proximity Read

A tug-of-war between germ cell motility and intercellular bridges controls germline cyst formation in miceSemantic proximity Read

Stem cells commit to differentiation following multiple induction events in the Drosophila testisSemantic proximity Read

Cyclin A associates with the fusome during germline cyst formation in the Drosophila ovary.Semantic proximity Read

NuRD chromatin remodeling is required to repair exogenous DSBs in the <i>Caenorhabditis elegans</i> germlineSemantic proximity Read

Nuclear export in somatic cyst cells controls cyst cell-germline coordination and germline differentiation in the <i>Drosophila</i> testisSemantic proximity Read

A cell non-autonomous FOXO/DAF-16-mediated germline quality assurance program that responds to somatic DNA damageSemantic proximity Read