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Thermal Control of Engineered T-cells

30 Jul 2020

Abstract excerpt

Genetically engineered T-cells are being developed to perform a variety of therapeutic functions. However, no robust mechanisms exist to externally control the activity of T-cells at specific locations within the body. Such spatiotemporal control could help mitigate potential off-target toxicity due to incomplete molecular specificity in applications such as T-cell immunotherapy against solid tumors. Temperature...

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PMID: 32786924
DOI: 10.1021/acssynbio.0c00238

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