Article

Ion channel function of polycystin-2/polycystin-1 heteromer revealed by structure-guided mutagenesis

2024-11-22

Abstract excerpt

Autosomal-dominant polycystic kidney disease (ADPKD) is caused by mutations affecting polycystin-1 (PC1) or polycystin-2 (PC2). Recent structural data suggest that PC1 and PC2 can form heterotetrameric ion channels with a 3:1 stoichiometry, with the channel in a closed state. In this hetero-oligomeric formation three PC1 residues (R4100, R4107, and H4111) would work together with two PC2 residues (L677, N681) to b...

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Literature Corpus work: bb2f619c-889c-56e4-ac10-53ce202a909c
DOI: 10.1101/2024.11.22.624889

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