Article

Structural and evolutionary insights into DAF-12 interactions with transcriptional coactivators in parasitic nematodes

2026-03-11

Abstract excerpt

Parasitic nematodes infect billions of humans and livestock worldwide, causing major health and economic burdens, while the spread of anthelmintic resistance threatens current control strategies. A critical step in parasite infection is the resumption of development of infective third-stage larvae (iL3) upon host entry, a process controlled by the nuclear receptor DAF-12. Activation of DAF-12 by dafachronic acids...

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Literature Corpus work: bb2eef69-aaca-5473-a40d-995cbd7c25e1
DOI: 10.64898/2026.03.11.711005

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