Article

Characterization of the Endogenous DAF-12 Ligand and Its Use as an Anthelmintic Agent in <i>Strongyloides stercoralis</i>

2021-09-08

Abstract excerpt

<h4>ABSTRACT</h4> A prevalent feature of Strongyloides stercoralis is a life-long and potentially lethal infection that is due to the nematode parasite’s ability to autoinfect and, thereby, self-replicate within its host. Here, we investigated the role of the parasite’s nuclear receptor, Ss- DAF-12, in governing infection. We identified Δ7-DA as the endogenous Ss- DAF-12 ligand and elucidated the hormone’s bio...

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Literature Corpus work: 409e0349-d2f0-5e8b-b539-abf66dc486e0
DOI: 10.1101/2021.09.07.459359

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