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Article

TGF‐β: Master regulator of inflammation and fibrosis

4 Oct 2018

Abstract excerpt

Transforming growth factor-β (TGF-β) is one of the three related gene products TGF-β 1–3 that activate the activin-like kinase receptor, ALK5, to elicit a bewildering array of (patho)physiological effects. The label ‘master regulator’ is well justified, as TGF-β is a morphogen, inflammogen, immune- and inflammatory modulator, mediator of tissue remodelling and wound healing, a fibrogen and yet more functions are...

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PMID: 30284753
DOI: 10.1111/resp.13415

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