Article

CRISPR/Cas9 targeting of MCPyV T antigen in Merkel tumors

2021-02-15

Abstract excerpt

<h4>ABSTRACT</h4> Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer caused either by Merkel cell polyomavirus (MCPyV) T antigen gene expression, post integration (∼80% cases), or by UV mediated DNA damage. Viral-positive Merkel tumors are not only caused by but also oncogenically addicted to tumor antigen expression. In this study we used CRISPR-Cas9 based gene-editing to develop a potential therapeut...

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Literature Corpus work: bacd3e27-ddd6-554a-a10c-0d94ffd25fbc
DOI: 10.1101/2021.02.14.431142

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