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Article

Merkel cell carcinoma: a virus-induced human cancer.

Annual review of pathology - 1 Jan 2012

Chang Yuan, Moore Patrick S

Abstract excerpt

Merkel cell polyomavirus (MCV) is the first polyomavirus directly linked to human cancer, and its recent discovery helps to explain many of the enigmatic features of Merkel cell carcinoma (MCC). MCV is clonally integrated into MCC tumor cells, which then require continued MCV oncoprotein expression to survive. The integrated viral genomes have a tumor-specific pattern of tumor antigen gene mutation that...

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Share to Genome, Viral
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Merkel Cell

Share to DNA, Viral

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Source

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Identifiers

PMID: 21942528
DOI: 10.1146/annurev-pathol-011110-130227
PMCID: PMC3732449

Genes

MCC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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