Article

Small amounts of misassembly can have disproportionate effects on pangenome-based metagenomic analyses

2024-10-13

Abstract excerpt

Individual genes from microbiomes can drive host-level phenotypes. To help identify such candidate genes, several recent tools estimate microbial gene copy numbers directly from metagenomes. These tools rely on alignments to pangenomes, which in turn are derived from the set of all individual genomes from one species. While large-scale metagenomic assembly efforts have made pangenome estimates more complete, mixed...

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Literature Corpus work: ba9efd62-de5b-5841-b19a-159d086efa7a
DOI: 10.1101/2024.10.11.617902

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