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Human gut microbiome gene co-expression network reveals a loss in taxonomic and functional diversity in Parkinson’s disease

24 Jul 2025

Abstract excerpt

Gut microbiome alterations are linked to various diseases, including neurodegeneration, but their ecological and functional impacts remain unclear. Using integrated multi-omics (metagenomics and metatranscriptomics), we analyse microbiome gene co-expression networks in Parkinson's disease (PD) and healthy controls (HC). We observe a significant depletion of hub genes in PD, including genes involved in secondary...

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PMID: 40707492
DOI: 10.1038/s41522-025-00780-0

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