Article

Gene-centric metagenomic analyses reveal microbiome functional insights into diseases

2025-09-29

Abstract excerpt

The microbiome encodes millions of genes; however, understanding their role in human health remains challenging. Here, we developed MetaGEAR, a gene-centric analysis framework for metagenomic data. MetaGEAR constructs cohort-specific databases for efficient retrieval of gene annotations, abundances, and co-localization, while providing enhanced taxonomic resolution by integrating reference- and assembly-based appr...

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Literature Corpus work: d936cb37-f16f-5f73-8cb2-e0d0223d1551
DOI: 10.1101/2025.09.29.679262

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