Article

PTPN1/2 inhibits alveolar macrophage-mediated control of lung metastasis

2026-02-26

Abstract excerpt

Metastasis remains the leading cause of cancer mortality, yet effective therapies are limited. While therapeutic responses are influenced by organ-specific immune microenvironments, strategies to pharmacologically modulate these niches remain poorly defined. Here, using the clinical-stage inhibitor ABBV-CLS-484 (AC484) as a chemical probe, we demonstrate that systemic PTPN1/2 inhibition remodels the pulmonary myel...

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Literature Corpus work: ba9a8286-8991-54ba-b741-187ade196bdf
DOI: 10.64898/2026.02.25.707995

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