Article

Different signaling interpretations by PKC eta and theta control T cell function and exhaustion

2024-09-27

Abstract excerpt

<h4>SUMMARY</h4> Chronic antigen signaling drives CD8 + T cell exhaustion (T EX ) in cancer and chronic infection. However, how the kinase cascades downstream of the T cell receptor drive exhaustion is not understood. We found that continuous agonism of protein kinase C (PKC) causes degradation of PKC theta, but not PKC eta, and induces terminal T EX cells. During chronic infection, PKC theta is necessary to m...

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Literature Corpus work: ba77a7ab-ce5a-5b49-af97-0ecad2e5be5b
DOI: 10.1101/2024.09.26.615103

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