Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mitochondrial dynamics changes with age in an APPsw/PS1dE9 mouse model of Alzheimer’s disease

21 Jan 2017

Abstract excerpt

Increasing research suggests that mitochondrial defects play a major role in Alzheimer's disease (AD) pathogenesis. We aimed to better understand changes in mitochondria with the development and progression of AD. We compared APPsw/PS1dE9 transgenic mice at 3, 6, 9, and 12 months old as an animal model of AD and age-matched C57BL/6 mice as controls. The learning ability and spatial memory ability of APPsw/PS1dE9...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Metabolism and Genetic Disorders
Share to Mitochondrial Function and Pathology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28118288
DOI: 10.1097/wnr.0000000000000739

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mitochondrial dynamics changes with age in an APPsw/PS1dE9 mouse model of Alzheimer’s diseasePMID 28118288Read ↗

Early Mitochondrial Defects in the 5xFAD mouse model of Alzheimer’s DiseaseSemantic proximity Read ↗

Abnormal Mitochondrial Dynamics in the Pathogenesis of Alzheimer's DiseaseSemantic proximity Read ↗

Recent Advances of Mitochondrial Alterations in Alzheimer’s Disease: A Perspective of Mitochondrial Basic EventsSemantic proximity Read ↗

The role of abnormal mitochondrial dynamics in the pathogenesis of Alzheimer’s diseaseSemantic proximity Read ↗

Mitochondrial Dysfunction Contributes to the Pathogenesis of Alzheimer’s DiseaseSemantic proximity Read ↗

Alterations in Mitochondrial Quality Control in Alzheimer’s DiseaseSemantic proximity Read ↗

A partial reduction of Drp1 enhances mitophagy, autophagy, mitochondrial biogenesis, dendritic spines and synaptic activity in a transgenic Tau mouse model of Alzheimer diseaseSemantic proximity Read ↗

A Synergistic Dysfunction of Mitochondrial Fission/Fusion Dynamics and Mitophagy in Alzheimer's DiseaseSemantic proximity Read ↗

Inhibition of mitochondrial fragmentation protects against Alzheimer’s disease in rodent modelSemantic proximity Read ↗

The Mitochondrial Dynamics of Alzheimers Disease and Parkinsons Disease Offer Important Opportunities for Therapeutic InterventionSemantic proximity Read ↗

Impaired balance of mitochondrial fission and fusion in Alzheimer's disease.Semantic proximity Read ↗

Mfn2 ablation causes an oxidative stress response and eventual neuronal death in the hippocampus and cortexSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.