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Emergence of <i>mutH</i> <sup>V76G</sup> among longitudinal carbapenem resistant <i>Klebsiella pneumoniae</i> causing long-term colonization and recurrent infection disrupts DNA mismatch repair and results in a hypermutator phenotype

2025-11-17

Abstract excerpt

Although hypermutation due to Mut protein mutations that disrupt DNA mismatch repair has been characterized in some bacteria, its mechanisms and consequences in Klebsiella pneumoniae remain poorly defined. We analyzed 11 longitudinal KPC-3 carbapenemase-producing, ST258 K. pneumoniae isolates collected over ∼4 years from an immunocompromised patient with chronic colonization and recurrent infections. After ∼3.3...

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Literature Corpus work
ba3c74ca-7434-5b8c-9071-e8904988f36f
DOI
10.1101/2025.11.17.688822
Open publication

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Emergence of <i>mutH</i> <sup>V76G</sup> among longitudinal carbapenem resistant <i>Klebsiella pneumoniae</i> causing long-term colonization and recurrent infection disrupts DNA mismatch repair and results in a hypermutator phenotypeDOI 10.1101/2025.11.17.688822
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