Reduced catalytic activity of KPC β-lactamase can increase ceftazidime resistance.

Abstract excerpt

β-Lactamases confer bacterial resistance by hydrolyzing β-lactam antibiotics. Klebsiella pneumoniae carbapenemases (KPCs) are a major cause of resistance to carbapenems, but combinations of β-lactams with β-lactamase inhibitors, such as ceftazidime/avibactam, initially restored activity against these enzymes. However, treatment has driven the emergence of KPC variants that evade inhibition. Here we investigate...

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