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Article

The landscape of regulatory genes in brain-wide neuronal phenotypes of a vertebrate brain.

eLife - 13 Dec 2021

Zhang Hui, Wang Haifang, Shen Xiaoyu, Jia Xinling, Yu Shuguang, Qiu Xiaoying, Wang Yufan, Du Jiulin, Yan Jun, He Jie

Abstract excerpt

Multidimensional landscapes of regulatory genes in neuronal phenotypes at whole-brain levels in the vertebrate remain elusive. We generated single-cell transcriptomes of ~67,000 region- and neurotransmitter/neuromodulator-identifiable cells from larval zebrafish brains. Hierarchical clustering based on effector gene profiles ('terminal features') distinguished major brain cell types. Sister clusters at...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34895465
DOI: 10.7554/eLife.68224
PMCID: PMC8769648

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