Article

Sirt6 reprograms myofibers to oxidative type through CREB-dependent Sox6 suppression

2021-02-23

Abstract excerpt

<title>Abstract</title> <p>Expanding the exercise capacity of skeletal muscle is an emerging strategy to combat obesity-related metabolic diseases and this can be achieved by shifting skeletal muscle fibers toward slow-twitch oxidative type. Here, we report that Sirt6, an anti-aging histone deacetylase, is critical in regulating myofiber configuration toward oxidative type and that Sirt6 activator can be an exerc...

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Literature Corpus work: ba13fa3d-7825-533b-8b76-a818ee7773cd
DOI: 10.21203/rs.3.rs-196751/v1

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