Article
Energy sources identify metabolic phenotypes in pancreatic cancer.
Acta biochimica et biophysica Sinica - 1 Nov 2016
Liang Chen, Qin Yi, Zhang Bo, Ji Shunrong, Shi Si, Xu Wenyan, Liu Jiang, Xiang Jinfeng, Liang Dingkong, Hu Qiangsheng, Liu Liang, Liu Chen, Luo Guopei, Ni Quanxing, Xu Jin, Yu Xianjun
Abstract excerpt
Metabolic reprogramming is one of the emerging hallmarks of cancers. As a highly malignant tumor, pancreatic ductal adenocarcinoma (PDA) is not only a metabolic disease but also a heterogeneous disease. Heterogeneity induces PDA dependence on distinct nutritive substrates, thereby inducing different metabolic phenotypes. We stratified PDA into four phenotypes with distinct types of energy metabolism, including a...
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