Article

Lost in communication: How Müller glia cells fail to maintain retinal integrity in USH1C retinal organoids

2025-06-03

Abstract excerpt

Usher syndrome type 1, caused by pathogenic variants in the USH1C gene, leads to congenital deafness and progressive retinal degeneration resulting in vision loss. While auditory deficits can be compensated by cochlea implants and hearing aids, no treatment exists to prevent retinal degeneration. Here, we generated retinal organoids from induced pluripotent stem cells of two USH1C patients to elucidate the cellul...

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Literature Corpus work: c2673690-92e3-57fa-bfba-fc85a71ff8da
DOI: 10.1101/2025.06.03.657614

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