Article

SDF-1/CXCR4 inhibition prevents paradoxical generation of cisplatin-induced pro-metastatic niches

2020-10-26

Abstract excerpt

Platinum-based chemotherapy remains widely used in advanced non-small cell lung cancer (NSCLC) despite its ineffectiveness in long-term control of metastasis. Here, we uncover the interconnected pathways subtending cisplatin-induced metastasis promotion. We report that cisplatin treatment of tumor-free mice results in bone-marrow expansion of CCR2+CXCR4+Ly6C high inflammatory monocytes (IM) concomitantly with inc...

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Literature Corpus work: b9d21dd2-dcd3-56f3-b994-a07a1bfcae47
DOI: 10.1101/2020.10.26.355057

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