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Article

Extracellular vesicles from subjects with COPD modulate cancer initiating cells phenotype through HIF-1α shuttling.

Cell death & disease - 14 Oct 2023

Petraroia Ilaria, Ghidotti Patrizia, Bertolini Giulia, Pontis Francesca, Roz Luca, Balsamo Melissa, Suatoni Paola, Pastorino Ugo, Ferretti Anna Maria, Sozzi Gabriella, Fortunato Orazio

Abstract excerpt

Chronic obstructive pulmonary disease (COPD) is a risk factor for lung cancer development. COPD induces activation of hypoxia-induced signaling, causing remodeling of surrounding microenvironmental cells also modulating the release and cargo of their extracellular vesicles (EVs). We aimed to evaluate the potential role of circulating EVs from COPD subjects in lung cancer onset. Plasma-EVs were isolated by...

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Identifiers

PMID: 37838700
DOI: 10.1038/s41419-023-06212-1
PMCID: PMC10576796

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