Article

Rapid peripheral reprogramming of myelinated afferents drives human hyperalgesia

2026-02-08

Abstract excerpt

A small burn can render a large area of skin painfully tender. This widespread hyperalgesia protects injured tissue and is typically attributed to altered spinal cord mechanisms. Whether peripheral sensory afferents directly interact to contribute to hyperalgesia remains unclear. Using single-unit microneurography, we recorded cutaneous afferents before and after inducing localized TRPV1-mediated inflammatory flar...

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Literature Corpus work: c63785b2-7f77-51a9-b183-aeafaf2aa1a2
DOI: 10.64898/2026.02.05.703527

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