Article

ISX-9 manipulates endocrine progenitor fate revealing conserved intestinal lineages in mouse and human

2019-09-30

Abstract excerpt

Enteroendocrine cells (EECs) survey the gut luminal environment and co-ordinate hormonal, immune and neuronal responses to it. They exhibit well characterised physiological roles ranging from the control of local gut function to whole body metabolism, but little is known regarding the regulatory networks controlling their differentiation, especially in human gut. The small molecule Isoxazole-9 (ISX-9) stimulates n...

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Literature Corpus work: b9ac6c20-7820-5b22-aac7-1bdfb5093d1c
DOI: 10.1101/787788

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