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Article

Structure, function and amyloidogenic propensity of apolipoprotein A-I.

Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis - 1 Dec 2006

Obici Laura, Franceschini Guido, Calabresi Laura, Giorgetti Sofia, Stoppini Monica, Merlini Giampaolo, Bellotti Vittorio

Abstract excerpt

Apolipoprotein A-I, the major structural apolipoprotein of high-density lipoproteins, efficiently protects humans from cholesterol accumulation in tissues; however, it can cause systemic amyloidosis in the presence of peculiar amino acid replacements. The wild-type molecule also has an intrinsic tendency to generate amyloid fibrils that localise within the atherosclerotic plaques. The structure, folding and...

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Identifiers

PMID: 17107880
DOI: 10.1080/13506120600960288

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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