Article
Apolipoprotein A-I: the dual face of a protein.
FEBS letters - 1 Dec 2016
Arciello Angela, Piccoli Renata, Monti Daria Maria
Abstract excerpt
Conformational plasticity and flexibility are key structural features of ApoAI in lipid metabolism. Amyloidogenic single point mutations, associated with incurable familial amyloidosis with fibril deposition in peripheral organs, may have a dramatic impact on the structural and functional features of ApoAI. Here, the consistent body of data on ApoAI variants has been reviewed, with the aim of highlighting the...
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