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Article

Structural Basis for the Pro-amyloidogenic Action and Ligand Binding of a Novel W72R Variant of Human Apolipoprotein A-I.

Journal of molecular biology - 1 Oct 2026

Prokaeva Tatiana, Jayaraman Shobini, Klimtchuk Elena S, Libbey Caryn, Mendelson Lisa, Spencer Brian, Chen Hui, Van Le Nhat Hoang, Sanchez Aniel, Kelleher Neil L, Dasari Surendra, McPhail Ellen D, Pereira Lucas, Avissar Uri, Cerda Sandra, Wong Sherry, Lavatelli Francesca, Sanchorawala Vaishali, Gursky Olga

Abstract excerpt

Apolipoprotein A-I (apoA-I), the major structural and functional protein of plasma high-density lipoprotein (HDL), mediates cholesterol removal from the body and has other beneficial properties. APOA1 gene mutations can cause diseases including human hereditary AApoAI amyloidosis, a life-threatening multiorgan disorder caused by apoA-I misfolding and amyloid deposition. We report esophageal AApoAI amyloidosis in...

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Identifiers

PMID: 42341910
DOI: 10.1016/j.jmb.2026.169916
PMCID: PMC13373713

Genes

APOA1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 15 Oct 2026.

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