Article

Genes for 5’mRNA cap binding proteins, <i>eif4ea</i> and <i>eif4eb</i> , have alternative roles during heart regeneration

2025-05-30

Abstract excerpt

<h4>ABSTRACT</h4> All eukaryotes possess the essential mRNA cap-binding protein eIF4E, which initiates translation. This protein is highly conserved, with versions from zebrafish and humans able to rescue yeast. All fish also have an additional eIF4E family, called eif4e1c , which is crucial for heart regeneration. Deletion of eif4e1c leads to growth defects and impaired heart regeneration, but it’s unclear if...

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Literature Corpus work: b995d6be-ecad-5391-a289-ba46cc738ab5
DOI: 10.1101/2025.05.27.656424

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