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Article

Genes for 5'mRNA cap binding proteins, eif4ea and eif4eb, have alternative roles during heart regeneration.

Developmental biology - 1 Jun 2026

Dockery Rejenae, Zevallos Mateo, McNulty Carson, Zecchino Tessa, Ratermann Reece, White Richard, Kolonay Dominic, Baskin Kedryn, Goldman Joseph Aaron

Abstract excerpt

All eukaryotes possess the essential mRNA cap-binding protein eIF4E, which initiates translation. This protein is highly conserved, with versions from zebrafish and humans able to rescue yeast. All fish also have an ancestral eIF4E family, called eif4e1c, which is crucial for heart regeneration. Deletion of eif4e1c leads to growth defects and impaired heart regeneration, but it's unclear if similar effects occur...

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Identifiers

PMID: 41802658
DOI: 10.1016/j.ydbio.2026.02.014
PMCID: PMC13373888

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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