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Highly Sensitive and Specific Amyloid-β Oligomers Detection Using CRISPR-Cas12a Probe System aided by Graphene Oxide for Early Diagnosis of Alzheimer’s Diseases

2022-09-28

Abstract excerpt

Alzheimer’s disease (AD) is highly age-specific that results in cognitive incapability including dementia. It is proposed that AD is caused by the dysfunctional gene producing excessive amyloid-β protein that eventually results in aggregated form of amyloid-β Oligomers (AβO). We couple the CRISPR-Cas12a system with a specially designed single-stranded DNA (ssDNA) aptamer that specifically forms a hybrid complex wi...

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Literature Corpus work: f090d4c3-a5f3-5781-bfcc-2d3bd2f22eaa
DOI: 10.1101/2022.09.27.509482

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Highly Sensitive and Specific Amyloid-β Oligomers Detection Using CRISPR-Cas12a Probe System aided by Graphene Oxide for Early Diagnosis of Alzheimer’s DiseasesDOI 10.1101/2022.09.27.509482Read

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