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MicroRNA-140-5p Suppresses The PD-L1 Level In Exosomes Derived From Hepatocellular Carcinoma Cells, Thereby Attenuating The Chemoresistance, Autophagy And Stemness Induced By Sorafenib In Hepatocellular Carcinoma

2021-09-13

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Sorafenib (SO), inhibitor of receptor tyrosine kinase, possesses anti-tumor ability in hepatocellular carcinoma (HCC) by anti-angiogenic effects. However, patients with advanced HCC are resistant to SO. Dysregulated micro-RNA (miRNA) has been shown to be associated with the drug resistance of tumors. Little is known about the effect of miRNA-140-5p on SO-resista...

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Literature Corpus work: 0d1c5551-87da-5a71-9c01-6f67f5f08a7d
DOI: 10.21203/rs.3.rs-845796/v1

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