Article

A conserved epilepsy-associated gene co-expression module identifies increased metabolic rate as a shared pathomechanism

2025-02-06

Abstract excerpt

Epilepsy is a mechanistically complex, incompletely understood neurological disorder. To uncover novel converging mechanisms in epilepsy, we used Drosophila whole-brain single-cell RNA-sequencing to refine and characterize a previously proposed human epilepsy-associated gene co-expression network (GCN). We identified a conserved co-expressed module of 26 genes, which comprises fly orthologs of 13 epilepsy-associat...

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Literature Corpus work: b951beae-d8cf-5007-bab6-129736d6546f
DOI: 10.1101/2025.02.03.636180

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