Article

<i>Pseudomonas aeruginosa</i> core metabolism exerts a widespread growth-independent control on virulence

2019-11-20

Abstract excerpt

Bacterial virulence may rely on secondary metabolism, but core metabolism genes are assumed to be necessary primarily for bacterial growth. To assess this assumption, we correlated the genome, the transcriptome and the pathogenicity of 30 fully sequenced Pseudomonas strains using two Drosophila and one mouse infection assay. In accordance with previous studies gene presence-absence does not explain differences i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b9443d39-4c58-5439-ab70-8ebbfe493e7a
DOI: 10.1101/850206

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>Pseudomonas aeruginosa</i> core metabolism exerts a widespread growth-independent control on virulenceDOI 10.1101/850206Read

Pseudomonas aeruginosa core metabolism exerts a widespread growth-independent control on virulence.Semantic proximity Read

Reconstruction of the metabolic network of Pseudomonas aeruginosa to interrogate virulence factor synthesis.Semantic proximity Read

<i>Pseudomonas aeruginosa</i> essential gene perturbations that confer vulnerability to the mammalian host environmentSemantic proximity Read

Genome-scale modeling of <i>Pseudomonas aeruginosa</i> PA14 unveils its broad metabolic capabilities and role of metabolism in drug potentiationSemantic proximity Read

Model-driven characterization of functional diversity of <i>Pseudomonas aeruginosa</i> clinical isolates with broadly representative phenotypesSemantic proximity Read

Systems-wide dissection of organic acid assimilation in <i>Pseudomonas aeruginosa</i> reveals a novel path to underground metabolismSemantic proximity Read

Genome-wide high-density CRISPR interference screens reveal condition-specific metabolic vulnerabilities in <i>Pseudomonas aeruginosa</i> PAO1Semantic proximity Read

Elucidating essential genes in plant-associated <i>Pseudomonas protegens</i> Pf-5 using transposon insertion sequencingSemantic proximity Read

Atypical BlaIR Two-Component System in <i>Pseudomonas aeruginosa</i> Regulates Virulence but not β-Lactam ResistanceSemantic proximity Read

Model-driven characterization of functional diversity of Pseudomonas aeruginosa clinical isolates with broadly representative phenotypes.Semantic proximity Read

Golden pigment production and virulence gene expression are affected by metabolisms in Staphylococcus aureus.Semantic proximity Read

Metabolic basis for the evolution of a common pathogenic <i>Pseudomonas aeruginosa</i> variantSemantic proximity Read