Article
Golden pigment production and virulence gene expression are affected by metabolisms in Staphylococcus aureus.
Journal of bacteriology - 1 Jun 2010
Lan Lefu, Cheng Alice, Dunman Paul M, Missiakas Dominique, He Chuan
Abstract excerpt
The pathogenesis of staphylococcal infections is multifactorial. Golden pigment is an eponymous feature of the human pathogen Staphylococcus aureus that shields the microbe from oxidation-based clearance, an innate host immune response to infection. Here, we screened a collection of S. aureus transposon mutants for pigment production variants. A total of 15 previously unidentified genes were discovered. Notably,...
Topics
- Abscess
- Animals
- Bacterial Proteins
- Farnesyl-Diphosphate Farnesyltransferase
- Gene Expression Regulation, Bacterial
- Metabolic Networks and Pathways
- Mice
- Mice, Inbred BALB C
- Mutation
- Pigments, Biological
- Protein Array Analysis
- Staphylococcal Infections
- Staphylococcus aureus