Article

Metabolic basis for the evolution of a common pathogenic <i>Pseudomonas aeruginosa</i> variant

2022-01-14

Abstract excerpt

Microbes frequently evolve in reproducible ways. Here, we show that differences in specific metabolic regulation explain the frequent presence of lasR loss-of-function mutations in the bacterial pathogen Pseudomonas aeruginosa. While LasR contributes to virulence, lasR mutants have been associated with more severe disease. A model based on the intrinsic growth kinetics for a wild type strain and its LasR - der...

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Literature Corpus work: 24d05036-e004-5d8b-b706-a9bead3cace9
DOI: 10.1101/2022.01.14.476307

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