Article

Human papillomavirus 16 E6 and E7 synergistically repress innate immune gene transcription

2019-11-13

Abstract excerpt

Human papillomaviruses are causative agents in 5% of all cancers, including the majority of anogenital and oropharyngeal cancers. Downregulation of innate immune genes (IIGs) by HPV to promote the viral life cycle is well documented; E6 and E7 are known repressors of these genes. More recently we demonstrated that E2 could also repress IIGs. These studies have been carried out in cells over-expressing the viral pr...

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Literature Corpus work: b9126e4e-dbf8-5e1f-b63f-1e6762590db8
DOI: 10.1101/841007

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